Pharma APIs
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Fmoc-Gly-Gly-OH
Fmoc-Gly-Gly-OH jẹ dipeptide ti a lo bi ipilẹ ile ipilẹ ni iṣelọpọ peptide ti o lagbara (SPPS). O ṣe ẹya awọn iṣẹku glycine meji ati N-terminus ti o ni aabo Fmoc, gbigba fun elongation pq peptide iṣakoso. Nitori iwọn kekere ti glycine ati irọrun, dipeptide yii ni a maa n ṣe iwadi ni gbogbo igba ti awọn iyipada ẹhin peptide, apẹrẹ ọna asopọ, ati awoṣe igbekalẹ ni awọn peptides ati awọn ọlọjẹ.
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Fmoc-Thr (tBu) -Phe-OH
Fmoc-Thr(tBu) -Phe-OH jẹ bulọọki ile dipeptide ti o wọpọ ti a lo ni iṣelọpọ peptide-alakoso ti o lagbara (SPPS). Ẹgbẹ Fmoc (9-fluorenylmethyloxycarbonyl) ṣe aabo fun N-terminus, lakoko ti ẹgbẹ tBu (tert-butyl) ṣe aabo pq ẹgbẹ hydroxyl ti threonine. Dipeptide ti o ni aabo yii ni a ṣe iwadi fun ipa rẹ ni irọrun elongation peptide daradara, idinku isọdi-ije, ati ṣe apẹẹrẹ awọn ero-tẹle kan pato ninu eto amuaradagba ati awọn ikẹkọ ibaraenisepo.
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AEEA-AEEA
AEEA-AEEA jẹ hydrophilic, spacer rọ ti o wọpọ ti a lo ninu peptide ati iwadii iṣọpọ oogun. O ni awọn iwọn orisun-ethylene glycol meji, ti o jẹ ki o wulo fun kikọ ẹkọ awọn ipa ti gigun asopọ ati irọrun lori awọn ibaraẹnisọrọ molikula, solubility, ati iṣẹ-ṣiṣe ti ibi. Awọn oniwadi nigbagbogbo lo awọn ẹya AEEA lati ṣe iṣiro bii awọn alafo ṣe ni ipa lori iṣẹ ti awọn conjugates antibody-oògùn (ADCs), awọn conjugates-oògùn peptide, ati awọn bioconjugates miiran.
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![Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide10-300x300.png)
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH
Apapọ yii jẹ aabo, itọsẹ lysine ti iṣẹ ṣiṣe ti a lo ninu iṣelọpọ peptide ati idagbasoke idapọ oogun. O ṣe ẹya ẹgbẹ Fmoc kan fun aabo N-terminal, ati iyipada pq ẹgbẹ pẹlu Eic (OtBu) (itọsẹ eicosanoic acid), γ-glutamic acid (γ-Glu), ati AEEA (aminoethoxyethoxyacetate). Awọn paati wọnyi jẹ apẹrẹ lati ṣe iwadi awọn ipa lipidation, kemistri spacer, ati itusilẹ oogun iṣakoso. O ti ṣe iwadii lọpọlọpọ ni aaye ti awọn ilana prodrug, awọn ọna asopọ ADC, ati awọn peptides ibaraenisepo awọ ara.
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![Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide9-300x300.png)
Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH
Apapọ yii jẹ itọsẹ lysine ti a ṣe atunṣe ti a lo ninu iṣelọpọ peptide, ni pataki fun ṣiṣe awọn ifọkansi tabi awọn conjugates peptide multifunctional. Ẹgbẹ Fmoc ngbanilaaye fun iṣelọpọ igbesẹ nipasẹ Fmoc solid-phase peptide synthesis (SPPS). Ẹwọn ẹgbẹ jẹ atunṣe pẹlu itọsẹ stearic acid (Ste), γ-glutamic acid (γ-Glu), ati awọn asopọ AEEA meji (aminoethoxyethoxyethoxyacetate), eyiti o pese hydrophobicity, awọn ohun-ini idiyele, ati aye to rọ. O jẹ iwadi ni igbagbogbo fun ipa rẹ ninu awọn eto ifijiṣẹ oogun, pẹlu awọn conjugates antibody-oògùn (ADCs) ati awọn peptides ti nwọle sẹẹli.
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Boc-His (Trt) -Aib-Gln (Trt)-Gly-OH
Boc-His (Trt) -Aib-Gln (Trt)-Gly-OHjẹ tetrapeptide ti o ni aabo ti a lo ninu iṣelọpọ peptide ati awọn ẹkọ igbekalẹ. Ẹgbẹ Boc (tert-butyloxycarbonyl) ṣe aabo fun N-terminus, lakoko ti awọn ẹgbẹ Trt (trtyl) ṣe aabo awọn ẹwọn ẹgbẹ ti histidine ati glutamine lati yago fun awọn aati aifẹ. Iwaju Aib (α-aminoisobutyric acid) ṣe igbelaruge awọn imudara helical ati mu iduroṣinṣin peptide ṣe. peptide yii ṣeyelori fun ṣiṣewadii kika peptide, iduroṣinṣin, ati bi scaffold fun sisọ awọn peptides ti nṣiṣe lọwọ biologically.
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Boc-Tyr (tBu) -Aib-Glu (OtBu) - Gly-OH
Boc-Tyr (tBu) -Aib-Glu (OtBu) - Gly-OHjẹ tetrapeptide ti o ni aabo ti o wọpọ ti a lo ninu iwadii iṣelọpọ peptide. Awọn ẹgbẹ Boc (tert-butyloxycarbonyl) ati tBu (tert-butyl) ṣiṣẹ bi awọn ẹgbẹ aabo lati ṣe idiwọ awọn aati ẹgbẹ lakoko apejọ pq peptide. Ifisi ti Aib (α-aminoisobutyric acid) ṣe iranlọwọ lati fa awọn ẹya helical ati mu iduroṣinṣin peptide pọ si. Ilana peptide yii ni a ṣe iwadi fun agbara rẹ ni itupalẹ conformational, kika peptide, ati bi bulọọki ile ni idagbasoke awọn peptides bioactive pẹlu imudara imudara ati pato.
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Fmoc-Ile-Aib-OH
Fmoc-Ile-Aib-OH jẹ bulọọki ile dipeptide ti a lo ninu iṣelọpọ peptide-alakoso to lagbara (SPPS). O daapọ Fmoc-idaabobo isoleucine pẹlu Aib (α-aminoisobutyric acid), amino acid ti kii ṣe adayeba ti o mu iduroṣinṣin helix ati resistance protease.
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![Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide6-300x300.png)
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH
Fmoc-L-Lys [Eic (OtBu)-γ-Glu (OtBu) -AEEA-AEEA] -OH jẹ bulọọki ile amino acid ti o ṣiṣẹ ti a ṣe apẹrẹ fun ifijiṣẹ oogun ti a fojusi ati bioconjugation. O ṣe ẹya ara Eic (eicosanoid) fun ibaraenisepo ọra, γ-Glu fun ìfọkànsí, ati AEEA spacers fun irọrun.
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Boc-Tyr (tBu)-Aib-OH
Boc-Tyr (tBu) -Aib-OH jẹ ile dipeptide ti o ni aabo ti a lo ninu iṣelọpọ peptide, apapọ Boc-idaabobo tyrosine ati Aib (α-aminoisobutyric acid). Iyoku Aib ṣe alekun idasile helix ati resistance protease.
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Boc-His (Trt)-Ala-Glu(OtBu)-Gly-OH
Boc-His (Trt) -Ala-Glu (OtBu) - Gly-OH jẹ idabobo tetrapeptide ti o ni aabo ti a lo ninu iṣelọpọ peptide ti o lagbara (SPPS) ati idagbasoke oogun peptide. O pẹlu awọn ẹgbẹ aabo fun kolaginni orthogonal ati awọn ẹya kan ti o wulo ọkọọkan ninu bioactive ati apẹrẹ peptide igbekale.
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Fmoc-Lys(Pal-Glu-OtBu)-OH
Fmoc-Lys(Pal-Glu-OtBu) -OH jẹ bulọọki ile amino acid lipidated amọja ti a ṣe apẹrẹ fun isopọpọ peptide–ọra. O ṣe ẹya lysine ti o ni aabo Fmoc pẹlu ẹwọn ẹgbẹ palmitoyl-glutamate, imudara ijora awọ ati bioavailability.