Awọn eroja Pharma
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iṣuu soda Inclisiran
Inclisiran sodium API (Ero elegbogi Ti nṣiṣe lọwọ) ni a ṣe iwadi ni akọkọ ni aaye kikọlu RNA (RNAi) ati awọn itọju ailera inu ọkan. Gẹgẹbi siRNA ti o ni ilọpo meji ti o fojusi jiini PCSK9, o jẹ lilo ni iṣaaju ati iwadii ile-iwosan lati ṣe iṣiro awọn ọgbọn ipalọlọ jiini ti n ṣiṣẹ pipẹ fun idinku LDL-C (idaabobo lipoprotein iwuwo kekere). O tun ṣe iranṣẹ bi akojọpọ awoṣe fun ṣiṣewadii awọn ọna ṣiṣe ifijiṣẹ siRNA, iduroṣinṣin, ati awọn itọju ailera RNA ti a fojusi ẹdọ.
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Fmoc-Gly-Gly-OH
Fmoc-Gly-Gly-OH jẹ dipeptide ti a lo bi ipilẹ ile ipilẹ ni iṣelọpọ peptide ti o lagbara (SPPS). O ṣe ẹya awọn iṣẹku glycine meji ati N-terminus ti o ni aabo Fmoc, gbigba fun elongation pq peptide iṣakoso. Nitori iwọn kekere ti glycine ati irọrun, dipeptide yii ni a maa n ṣe iwadi ni gbogbo igba ti awọn iyipada ẹhin peptide, apẹrẹ ọna asopọ, ati awoṣe igbekalẹ ni awọn peptides ati awọn ọlọjẹ.
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Fmoc-Thr (tBu) -Phe-OH
Fmoc-Thr(tBu) -Phe-OH jẹ bulọọki ile dipeptide ti o wọpọ ti a lo ni iṣelọpọ peptide-alakoso ti o lagbara (SPPS). Ẹgbẹ Fmoc (9-fluorenylmethyloxycarbonyl) ṣe aabo fun N-terminus, lakoko ti ẹgbẹ tBu (tert-butyl) ṣe aabo pq ẹgbẹ hydroxyl ti threonine. Dipeptide ti o ni aabo yii ni a ṣe iwadi fun ipa rẹ ni irọrun elongation peptide daradara, idinku isọdi-ije, ati ṣe apẹẹrẹ awọn ero-tẹle kan pato ninu eto amuaradagba ati awọn ikẹkọ ibaraenisepo.
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AEEA-AEEA
AEEA-AEEA jẹ hydrophilic, spacer rọ ti o wọpọ ti a lo ninu peptide ati iwadii iṣọpọ oogun. O ni awọn iwọn orisun-ethylene glycol meji, ti o jẹ ki o wulo fun kikọ ẹkọ awọn ipa ti gigun asopọ ati irọrun lori awọn ibaraẹnisọrọ molikula, solubility, ati iṣẹ-ṣiṣe ti ibi. Awọn oniwadi nigbagbogbo lo awọn ẹya AEEA lati ṣe iṣiro bii awọn alafo ṣe ni ipa lori iṣẹ ti awọn conjugates antibody-oògùn (ADCs), awọn conjugates-oògùn peptide, ati awọn bioconjugates miiran.
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![Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide10-300x300.png)
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH
Apapọ yii jẹ aabo, itọsẹ lysine ti iṣẹ ṣiṣe ti a lo ninu iṣelọpọ peptide ati idagbasoke idapọ oogun. O ṣe ẹya ẹgbẹ Fmoc kan fun aabo N-terminal, ati iyipada pq ẹgbẹ pẹlu Eic (OtBu) (itọsẹ eicosanoic acid), γ-glutamic acid (γ-Glu), ati AEEA (aminoethoxyethoxyacetate). Awọn paati wọnyi jẹ apẹrẹ lati ṣe iwadi awọn ipa lipidation, kemistri spacer, ati itusilẹ oogun iṣakoso. O ti ṣe iwadii lọpọlọpọ ni aaye ti awọn ilana prodrug, awọn ọna asopọ ADC, ati awọn peptides ibaraenisepo awọ ara.
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![Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide9-300x300.png)
Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH
Apapọ yii jẹ itọsẹ lysine ti a ṣe atunṣe ti a lo ninu iṣelọpọ peptide, ni pataki fun ṣiṣe awọn ifọkansi tabi awọn conjugates peptide multifunctional. Ẹgbẹ Fmoc ngbanilaaye fun iṣelọpọ igbesẹ nipasẹ Fmoc solid-phase peptide synthesis (SPPS). Ẹwọn ẹgbẹ jẹ atunṣe pẹlu itọsẹ stearic acid (Ste), γ-glutamic acid (γ-Glu), ati awọn asopọ AEEA meji (aminoethoxyethoxyethoxyacetate), eyiti o pese hydrophobicity, awọn ohun-ini idiyele, ati aye to rọ. O jẹ iwadi ni igbagbogbo fun ipa rẹ ninu awọn eto ifijiṣẹ oogun, pẹlu awọn conjugates antibody-oògùn (ADCs) ati awọn peptides ti nwọle sẹẹli.
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Boc-His (Trt) -Aib-Gln (Trt)-Gly-OH
Boc-His (Trt) -Aib-Gln (Trt)-Gly-OHjẹ tetrapeptide ti o ni aabo ti a lo ninu iṣelọpọ peptide ati awọn ẹkọ igbekalẹ. Ẹgbẹ Boc (tert-butyloxycarbonyl) ṣe aabo fun N-terminus, lakoko ti awọn ẹgbẹ Trt (trtyl) ṣe aabo awọn ẹwọn ẹgbẹ ti histidine ati glutamine lati yago fun awọn aati aifẹ. Iwaju ti Aib (α-aminoisobutyric acid) ṣe igbelaruge awọn iṣeduro helical ati ki o mu iduroṣinṣin peptide. peptide yii ṣeyelori fun ṣiṣewadii kika peptide, iduroṣinṣin, ati bi scaffold fun sisọ awọn peptides ti nṣiṣe lọwọ biologically.
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Boc-Tyr (tBu) -Aib-Glu (OtBu) - Gly-OH
Boc-Tyr (tBu) -Aib-Glu (OtBu) - Gly-OHjẹ tetrapeptide ti o ni aabo ti o wọpọ ti a lo ninu iwadii iṣelọpọ peptide. Awọn ẹgbẹ Boc (tert-butyloxycarbonyl) ati tBu (tert-butyl) ṣiṣẹ bi awọn ẹgbẹ aabo lati ṣe idiwọ awọn aati ẹgbẹ lakoko apejọ pq peptide. Ifisi ti Aib (α-aminoisobutyric acid) ṣe iranlọwọ lati fa awọn ẹya helical ati mu iduroṣinṣin peptide pọ si. Ilana peptide yii ni a ṣe iwadi fun agbara rẹ ni itupalẹ conformational, kika peptide, ati bi bulọọki ile ni idagbasoke awọn peptides bioactive pẹlu imudara imudara ati pato.
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Fmoc-Ile-Aib-OH
Fmoc-Ile-Aib-OH jẹ bulọọki ile dipeptide ti a lo ninu iṣelọpọ peptide-alakoso to lagbara (SPPS). O daapọ Fmoc-idaabobo isoleucine pẹlu Aib (α-aminoisobutyric acid), amino acid ti kii ṣe adayeba ti o mu iduroṣinṣin helix ati resistance protease.
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![Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide6-300x300.png)
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH
Fmoc-L-Lys [Eic (OtBu)-γ-Glu (OtBu) -AEEA-AEEA] -OH jẹ bulọọki ile amino acid ti o ṣiṣẹ ti a ṣe apẹrẹ fun ifijiṣẹ oogun ti a fojusi ati bioconjugation. O ṣe ẹya ara Eic (eicosanoid) fun ibaraenisepo ọra, γ-Glu fun ìfọkànsí, ati AEEA spacers fun irọrun.
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Boc-Tyr (tBu)-Aib-OH
Boc-Tyr (tBu) -Aib-OH jẹ ile dipeptide ti o ni aabo ti a lo ninu iṣelọpọ peptide, apapọ Boc-idaabobo tyrosine ati Aib (α-aminoisobutyric acid). Iyoku Aib ṣe alekun idasile helix ati resistance protease.
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Boc-His (Trt)-Ala-Glu(OtBu)-Gly-OH
Boc-His (Trt) -Ala-Glu (OtBu) - Gly-OH jẹ idabobo tetrapeptide ti o ni aabo ti a lo ninu iṣelọpọ peptide ti o lagbara (SPPS) ati idagbasoke oogun peptide. O pẹlu awọn ẹgbẹ aabo fun kolaginni orthogonal ati awọn ẹya kan ti o wulo ọkọọkan ninu bioactive ati apẹrẹ peptide igbekale.