Caspofungin fun awọn akoran Antifungal
Alaye ọja
| Oruko | Caspofungin |
| nọmba CAS | 162808-62-0 |
| Ilana molikula | C52H88N10O15 |
| Ìwúwo molikula | 1093.31 |
| Nọmba EINECS | 1806241-263-5 |
| Oju omi farabale | 1408.1± 65.0 °C (Asọtẹlẹ) |
| iwuwo | 1.36± 0.1 g/cm3(Asọtẹlẹ) |
| olùsọdipúpọ acidity | (pKa) 9.86± 0.26 (Asọtẹlẹ) |
Awọn itumọ ọrọ sisọ
CS-1171; Caspofungine; CASPOFUNGIN; CASPORFUNGIN; PneuMocandinB0,1-[(4R,5S) -5-[(2-aMinoethyl) aMino] -N2-(10,12-diMethyl). -1-oxotetradecyl) -4-hydroxy-L-ornithine] -5-[(3R) -3-hydroxy-L-ornithine] -; CaspofunginMK-0991; Aids058650; Aids-058650
Kemikali Properties
Caspofungin jẹ akọkọ echinocandin ti a fọwọsi fun itọju awọn akoran olu ti o nfa. Awọn idanwo in vitro ati in vivo jẹrisi pe caspofungin ni iṣẹ ṣiṣe antibacterial to dara lodi si awọn pathogens opportunistic pataki-Candida ati Aspergillus. Caspofungin le rupture ogiri sẹẹli nipa idinamọ iṣelọpọ ti 1,3-β-glucan. Ni ile-iwosan, caspofungin ni ipa to dara lori itọju ti ọpọlọpọ candidiasis ati aspergillosis.
Ipa
(1,3) -D-glucan synthase jẹ paati bọtini ti iṣelọpọ ogiri sẹẹli olu, ati caspofungin le ṣe ipa ipa antifungal nipasẹ idilọwọ awọn enzymu yii laisi idije. Lẹhin iṣakoso iṣọn-ẹjẹ, ifọkansi oogun pilasima silẹ ni iyara nitori pinpin awọn ara, atẹle nipa itusilẹ mimu oogun naa lati ara. Metabolism ti caspofungin pọ si pẹlu iwọn lilo ti o pọ si ati pe o ni ibatan iwọn lilo ni akoko si ipo iduroṣinṣin pẹlu awọn abere pupọ. Nitorinaa, lati ṣaṣeyọri awọn ipele itọju ailera ti o munadoko ati yago fun ikojọpọ oogun, iwọn lilo ikojọpọ akọkọ yẹ ki o ṣe abojuto iwọn lilo itọju kan. Nigbati o ba nlo awọn inducers cytochrome p4503A4 ni akoko kanna, gẹgẹbi rifampicin, carbamazepine, dexamethasone, phenytoin, bbl, o niyanju lati mu iwọn itọju ti caspofungin pọ si.
Awọn itọkasi
Awọn itọkasi FDA-fọwọsi fun caspofungin pẹlu: 1. Iba pẹlu neutropenia: ti a ṣalaye bi: iba>38°C pẹlu iye neutrophil pipe (ANC) ≤500/ml, tabi pẹlu ANC ≤1000/ml ati pe o le dinku si isalẹ 500/ml. Gẹgẹbi iṣeduro ti Awujọ Arun Inu Arun ti Amẹrika (IDSA), botilẹjẹpe awọn alaisan ti o ni iba ti o tẹsiwaju ati neutropenia ti ni itọju pẹlu awọn oogun aporo-ọpọlọ gbooro, awọn alaisan ti o ni eewu ti o ga ni a tun ṣeduro lati lo itọju antifungal empiric, pẹlu caspofungin ati awọn oogun antifungal miiran. . 2. Candidiasis invasive: IDSA ṣe iṣeduro echinocandins (gẹgẹbi caspofungin) gẹgẹbi oogun ti o yan fun candidemia. O tun le ṣee lo lati ṣe itọju awọn abscesses inu-inu, peritonitis ati awọn akoran àyà ti o fa nipasẹ ikolu Candida. 3. Esophageal candidiasis: Caspofungin le ṣee lo lati ṣe itọju candidiasis esophageal ni awọn alaisan ti o ni ifarabalẹ tabi ailagbara si awọn itọju ailera miiran. Ọpọlọpọ awọn ijinlẹ ti rii pe ipa itọju ailera ti caspofungin jẹ afiwera si ti fluconazole. 4. Aspergillosis invasive: A ti fọwọsi Caspofungin fun itọju aspergillosis invasive ni awọn alaisan ti o ni ailagbara, resistance, ati ailagbara ti oogun antifungal akọkọ, voriconazole. Sibẹsibẹ, echinocandin ko ṣe iṣeduro bi itọju ailera akọkọ.
