Daptomycin 103060-53-3 fun Awọn Arun Arun
Apejuwe ọja
| Oruko | Daptomycin |
| nọmba CAS | 103060-53-3 |
| Ilana molikula | C72H101N17O26 |
| Ìwúwo molikula | 1620.67 |
| Nọmba EINECS | 600-389-2 |
| Ojuami yo | 202-204°C |
| Oju omi farabale | 2078.2± 65.0 °C (Asọtẹlẹ) |
| iwuwo | 1.45±0.1 g/cm3(Asọtẹlẹ) |
| oju filaṣi | 87℃ |
| Awọn ipo ipamọ | Ti di ninu gbigbẹ, Fipamọ sinu firisa, labẹ -20 ° C |
| Solubility | Methanol: soluble5mg/ml |
| olùsọdipúpọ acidity | (pKa) 4.00± 0.10 (Asọtẹlẹ) |
| Fọọmu | lulú |
| Àwọ̀ | colorless to alãrẹ ofeefee |
Awọn itumọ ọrọ sisọ
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-] -cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp- Gly-D-Ser-[(3R) -3-methyl-L-Glu-] -4- (2-aminophenyl) -4-oxo-L-Abu-]; N-[N-Decanoyl-L-Trp- D-Asn-L-Asp-] -cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L- Glu-] -3- (2-aminobenzoyl) -L-Ala-]; N- (1-Oxodecyl) -L-tryptophyl-D-asparaginyl-L-a-aspartyl-L-threonylglycyl-L-ornithinyl-L- α-aspartyl-D-alanyl-L-a-aspartylglycyl-D-seryl- (3R) -3-methyl-L-a-glutamyl-a,2-diamino-γ-oxo-benzenebutanoicacid (13-4) lactone; DAPTOMYCINE; Dapcin; Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)
Apejuwe
Daptomycin aporo-ara jẹ oogun apakokoro lipopeptide cyclic pẹlu eto tuntun ti a fa jade lati inu omitooro bakteria ti Streptomyces (S. reseosporus), eyiti o ṣe idiwọ biosynthesis ti peptidoglycan ogiri sẹẹli nipa didamu gbigbe awọn amino acids ninu awo sẹẹli.Yiyipada awọn ohun-ini ti awọ ara cytoplasmic le ṣe idiwọ iṣẹ awo alawọ kokoro ni awọn ọna lọpọlọpọ ati ni iyara pa awọn kokoro arun to dara Giramu.Ni afikun si agbara rẹ lati ṣe lori ọpọlọpọ awọn kokoro arun Gram-positive ti ile-iwosan, daptomycin ṣe pataki diẹ sii fun awọn igara ti o ya sọtọ ti o ti ṣe afihan resistance si methicillin, vancomycin, ati linezolid in vitro.O ni iṣẹ ṣiṣe ti o lagbara, ati pe ohun-ini yii ni awọn ilolu ile-iwosan pataki pupọ fun awọn alaisan ti o ni akoran.Eosinophilic pneumonia jẹ arun ti o ṣọwọn ati pe o lewu pupọ pẹlu awọn aami aisan pẹlu iba, Ikọaláìdúró, kuru ẹmi, ati iṣoro mimi.
Ipa Antibacterial
Daptomycin ni iṣẹ-ṣiṣe bacteriostatic ti o dara lodi si ọpọlọpọ awọn kokoro arun ti ko ni egboogi, gẹgẹbi MIC = 0.06-0.5 μg/ml fun Staphylococcus aureus-sooro methicillin (MRSA), ati Staphylococcus aureus-sooro methicillin (MRSA).MIC=0.0625～1μg/ml fun kokoro arun, MIC=0.12～0.5μg/ml fun oxacillin-sooro Staphylococcus epidermidis, MIC=2.5μg/ml fun enterococcus gíga sooro si aminoglycoside aporo, MIC=2.5μg/ml fun GmrABIa ti Enterococcus jẹ 0.5 ~ 1μg / milimita, ati MIC ti Enterococcus sooro si awọn egboogi glycopeptide jẹ 1 ~ 2μg / milimita.
