Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

Fmoc-L-Lys[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH

Ohun elo Iwadi:
Apapọ yii jẹ itọsẹ lysine ti a ṣe atunṣe ti a lo ninu iṣelọpọ peptide, ni pataki fun ṣiṣe awọn ifọkansi tabi awọn conjugates peptide multifunctional. Ẹgbẹ Fmoc ngbanilaaye fun iṣelọpọ igbesẹ nipasẹ Fmoc solid-phase peptide synthesis (SPPS). Ẹwọn ẹgbẹ jẹ atunṣe pẹlu itọsẹ stearic acid (Ste), γ-glutamic acid (γ-Glu), ati awọn asopọ AEEA meji (aminoethoxyethoxyethoxyacetate), eyiti o pese hydrophobicity, awọn ohun-ini idiyele, ati aye to rọ. O jẹ iwadi ni igbagbogbo fun ipa rẹ ninu awọn eto ifijiṣẹ oogun, pẹlu awọn conjugates antibody-oògùn (ADCs) ati awọn peptides ti nwọle sẹẹli.

Iṣẹ:
Fmoc-L-Lys[Ste(OtBu))-γ-Glu(OtBu) – AEEA-AEEA]-OH awọn iṣẹ bi ohun amorindun fun idagbasoke awọn peptides lipidated pq gigun tabi awọn eka-ilana oogun. Awọn stearic acid ṣe alekun ibaramu awọ-ara, γ-Glu ṣe ilọsiwaju iduroṣinṣin ati resistance enzymatic, ati awọn ọna asopọ AEEA n pese solubility ati irọrun igbekalẹ. Papọ, awọn ẹya wọnyi jẹ ki agbo-ara naa niyelori ni sisọ awọn peptides fun ilọsiwaju bioavailability, idasilẹ iṣakoso, ati awọn ohun elo ifijiṣẹ ti a fojusi.