Sildenafil Citrate Itoju Ailera Erectile 171599-83-0
Alaye ọja
| Oruko | Sildenafil Citrate |
| nọmba CAS | 171599-83-0 |
| Ilana molikula | C28H38N6O11S |
| Ìwúwo molikula | 666.70 |
| Nọmba EINECS | 200-659-6 |
| Merck | 14.8489 |
| iwuwo | 1.445g/cm3 |
| Ipo ipamọ | 2-8°C |
| Fọọmu | Lulú |
| Àwọ̀ | Funfun |
| Omi solubility | DMSO:> 20mg/ml |
Awọn itumọ ọrọ sisọ
Viagra, Sildenafil citrate; 1-[[3- (4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4,3-d] pyrimidin-5-yl) -4-ethoxyphenyl] sulfonyl] -4-methylpiperazinecitratesalt; 5-[2-Ethoxy-5- (4-methylpiperazin-1-yl) sulfonylphenyl] -1-methyl-3-propyl-4H-pyrazolo [5,4-e] pyrimidin-7-onecitratesalt; 1-[[3- (6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4,3-d] pyrimidin-5-yl) -4-ethoxyphenyl] sulfonyl] -4-methylpiperazine,2-hydroxy-1,2,3-propanetricarboxylate; SildenafilCitrate (100mg); Sildenafilcitrate,>=99%;Sildenafilcitrate,Ipese ọjọgbọn; 5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl) sulfonyl] phenyl] -1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d] pyrimidin-7-onecitrate
Pharmacological Ipa
Pharmacological Action
Sildenafil citrate jẹ oludena 5-phosphodiesterase ti o yan ti o mu ki o gbẹkẹle-nitric oxide, cyclic guanosine monophosphate-mediated pulmonary vasodilation nipasẹ didasilẹ idinku ti cyclic guanosine monophosphate. Ni afikun si imugboroja taara ti awọn ohun elo ẹjẹ ẹdọforo, o tun le ṣe idiwọ tabi yiyipada atunṣe iṣan.
Awọn ohun-ini oogun ati Awọn ohun elo
Sildenafil citrate, orukọ iṣowo Viagre, ti a mọ ni Viagra, jẹ cyclic guanosine monophosphate (cGMP)-pato phosphodiesterase type 5 (PDE5) inhibitor ti o le mu ilọsiwaju pọ si lẹhin iṣakoso ẹnu. Sildenafil citrate le mu ipa ti nitric oxide (NO) ṣe nipasẹ didaduro iru 5 phosphodiesterase ti o dinku cyclic guanosine monophosphate (cGMP) ninu cavernosum corpus. Mu ipele ti cGMP pọ si ninu cavernosum corpus, sinmi iṣan dan ni corpus cavernosum, mu sisan ẹjẹ pọ si, fa akoko ikọlu kòfẹ ati mu iduroṣinṣin pọ si. Fun ailagbara alaisan pẹlu erectile alailoye. Awọn agbalagba gba 50 miligiramu ẹnu ni igba kọọkan, to 1 akoko ni ọjọ kan, ati lo bi o ṣe nilo nipa wakati 1 ṣaaju ibaraẹnisọrọ ibalopo. Iwọn to pọ julọ jẹ 0.1g ni igba kọọkan.
Ninu awọn ẹkọ vivo
Ninu awọn aja ti a ti ni anesthetized, Sildenafil citrate ṣe ilọsiwaju iṣẹ-ṣiṣe penile erectile labẹ ifarakan nafu ara pelvic nipasẹ wiwọn titẹ intracavernous. Sildenafil citrate ṣe afihan ifasilẹ ailagbara carbamoylcholine-isinmi ati idalọwọduro idasile superoxide ninu àsopọ cavernosal ti awọn ehoro hypercholesterolemic. Ni awọn eku Sprague-Dawley, Sildenafil ṣe ilọsiwaju iṣẹ erectile ni ọna ti o gbẹkẹle akoko-akoko, pẹlu imularada ti o pọju ti o waye ni ọjọ 28 ni iwọn lilo 20 mg / kg fun ọjọ kan. Ni awọn eku Sprague-Dawley, iṣakoso ti Sildenafil yorisi ni itọju ratio collagen isan dan ati itoju ti CD31 ati ikosile eNOS. Ni awọn eku Sprague-Dawley, Sildenafil dinku pataki itọka apoptotic ati pọ si phosphorylation ti akt ati eNOS ni akawe pẹlu ẹgbẹ iṣakoso.
