Vancomycin jẹ egboogi glycopeptide ti a lo fun antibacterial
Alaye ọja
| Oruko | Vancomycin |
| nọmba CAS | 1404-90-6 |
| Ilana molikula | C66H75Cl2N9O24 |
| Ìwúwo molikula | 1449.25 |
| Nọmba EINECS | 215-772-6 |
| iwuwo | 1.2882 (iṣiro ti o ni inira) |
| Atọka itọka | 1.7350 (iṣiro) |
| Awọn ipo ipamọ | Ti di ni gbẹ, 2-8 ° C |
Awọn itumọ ọrọ sisọ
Vancomycin (baseand/orunspecifiedsalts);VANCOMYCIN; VancomycinBase; (3S,6R,7R,22R,23S,26S,36R,38aR) -3-(2-Amino-2-oxoethyl) -44-[2-O-(3-amino-2, 3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl] oxy] -10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7 ,22,28,30,32-pentahydroxy-6-[[(2R) -4-methChemicalbookyl-2-(methylamino) -1-oxopentyl] amino]-2,5,24,38,39-pentaoxo-22H-8,11:18,21-Dietheno-23, 36-(iminomethano) -13,16:31,35-dimetheno-1H,16H-[1,6,9] oxadiazacyclohexadecino [4,5-m] [10,2,16] benzoxadiazacyclotetracosine-26-carboxylicacid.
Apejuwe
Vancomycin jẹ apakokoro glycopeptide. Ilana iṣe rẹ ni lati sopọ pẹlu isunmọ giga si alanylalanine ni opin poli-terminal ti peptide iṣaaju ti ogiri sẹẹli ti kokoro ifarabalẹ, idinamọ iṣelọpọ ti peptidoglycan macromolecular ti o jẹ ogiri sẹẹli ti kokoro, Abajade ni Iparun ogiri sẹẹli pa awọn kokoro arun. Vancomycin jẹ doko fun awọn akoran to ṣe pataki ti o fa nipasẹ awọn kokoro arun rere ti Giramu, paapaa awọn ti o fa nipasẹ Staphylococcus aureus-sooro methicillin, Staphylococcus epidermidis, ati Enterococcus ti o tako si awọn oogun apakokoro miiran tabi ti ko ni ipa.
Awọn itọkasi
O ti wa ni opin si awọn akoran eto-ara ti o fa nipasẹ Staphylococcus aureus-sooro methicillin (MRSA) ati awọn akoran inu ati awọn akoran eto ti o fa nipasẹ Clostridium difficile; penicillin-alaisan ko le lo awọn penicillins tabi cephalosporins ninu awọn alaisan ti o ni ikolu staphylococcal ti o lagbara, tabi awọn ti o ni ikolu staphylococcal ti o lagbara ti wọn kuna lati dahun si awọn oogun apakokoro loke, vancomycin le ṣee lo. A tun lo ọja yii fun itọju Enterococcus endocarditis ati Corynebacterium (diphtheria-like) endocarditis ninu awọn eniyan ti o ni inira si pẹnisilini. Itoju ti awọn akoran shunt arteriovenous ti staphylococcus ninu awọn alaisan hemodialysis ti o ni inira si pẹnisilini ati ti kii ṣe aleji si pẹnisilini.
![Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide10-300x300.png)
