Vancomycin jẹ egboogi glycopeptide ti a lo fun antibacterial
Apejuwe ọja
| Oruko | Vancomycin |
| nọmba CAS | 1404-90-6 |
| Ilana molikula | C66H75Cl2N9O24 |
| Ìwúwo molikula | 1449.25 |
| Nọmba EINECS | 215-772-6 |
| iwuwo | 1.2882 (iṣiro ti o ni inira) |
| Refractive Ìwé | 1.7350 (iṣiro) |
| Awọn ipo ipamọ | Ti di ni gbẹ, 2-8 ° C |
Awọn itumọ ọrọ sisọ
Vancomycin (baseand/orunspecifiedsalts);VANCOMYCIN; VancomycinBase; (3S,6R,7R,22R,23S,26S,36R,38aR) -3- (2-Amino-2-oxoethyl) -44-[[2-O-() 3-amino-2,3,6-trideoxy-3-C-methyl-a-L-lyxo-hexopyranosyl) -β-D-glucopyranosyl] oxy] -10,19-dichloro-2,3,4,5, 6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-[[(2R)-4-methChemicalbookyl-2-(methylamino) -1-oxopentyl]amino] -2,5,24,38,39-pentaoxo-22H-8,11:18,21-Dietheno-23,36-(iminomethano) -13,16:31,35-dimetheno -1H,16H-[1,6,9] oxadiazacyclohexadecino [4,5-m] [10,2,16] benzoxadiazacyclotetracosine-26-carboxylicacid.
Apejuwe
Vancomycin jẹ oogun apakokoro glycopeptide.Ilana iṣe rẹ ni lati sopọ pẹlu isunmọ giga si alanylalanine ni opin poli-terminal ti peptide iṣaaju ti ogiri sẹẹli ti o ni imọlara, idilọwọ iṣelọpọ ti peptidoglycan macromolecular ti o jẹ ogiri sẹẹli kokoro-arun, ti o yọrisi Iparun sẹẹli naa. odi pa kokoro arun.Vancomycin jẹ doko fun awọn akoran to ṣe pataki ti o fa nipasẹ awọn kokoro arun rere ti Giramu, paapaa awọn ti o fa nipasẹ Staphylococcus aureus-sooro methicillin, Staphylococcus epidermidis, ati Enterococcus ti o tako si awọn oogun apakokoro miiran tabi ti ko ni ipa.
Awọn itọkasi
O ti wa ni opin si awọn akoran eto-ara ti o fa nipasẹ Staphylococcus aureus-sooro methicillin (MRSA) ati awọn akoran inu ati awọn akoran eto ti o fa nipasẹ Clostridium difficile;penicillin-alaisan ko le lo awọn penicillins tabi cephalosporins ninu awọn alaisan ti o ni ikolu staphylococcal ti o lagbara, tabi awọn ti o ni ikolu staphylococcal ti o lagbara ti wọn kuna lati dahun si awọn oogun apakokoro ti o wa loke, vancomycin le ṣee lo.Ọja yii tun lo fun itọju Enterococcus endocarditis ati Corynebacterium (diphtheria-like) endocarditis ninu awọn eniyan ti o ni inira si pẹnisilini.Itoju awọn akoran shunt arteriovenous ti staphylococcus ninu awọn alaisan hemodialysis inira si pẹnisilini ati ti kii ṣe aleji si pẹnisilini.
