Eptifibatide fun Itoju Arun Arun Arun Arunrawọn 188627-80-7
Alaye ọja
| Oruko | Eptifibatide |
| nọmba CAS | 188627-80-7 |
| Ilana molikula | C35H49N11O9S2 |
| Ìwúwo molikula | 831.96 |
| Nọmba EINECS | 641-366-7 |
| iwuwo | 1.60±0.1 g/cm3(Asọtẹlẹ) |
| Awọn ipo ipamọ | Ti di ninu gbigbẹ, fipamọ sinu firisa, labẹ -15 ° C |
Awọn itumọ ọrọ sisọ
Eptifibatideacetatesalt; Eptifibatide,MPA-HAR-Gly-Asp-Trp-Pro-Cys-NH2,MPAHARGDWPC-NH2,>99%;MAP-LYS-GLY-ASP-TRP-PRO-CYS-NH2;INTEGRELIN;Eptifibatide; nomethyl) -N2- (3-mercapto-1-oxopropyl-L-lysylglycyl-La-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide;MPA-HAR-GLY-ASP-TRP-PRO-CYS-NH2(DISULFIDEBRIDGE,MPA1-CYS6).
Platelet Glycoprotein antagonist
Etifibatide (integrilin) jẹ aramada aramada polypeptide platelet glycoprotein IIb/IIIa antagonist olugba olugba, eyiti o ṣe idiwọ iṣakojọpọ platelet ati thrombosis nipa didi ipa ọna ti o wọpọ ti apapọ platelet. Ti a ṣe afiwe pẹlu monoclonal antibody abciximab, eptifibatide ni okun sii, itọsọna diẹ sii ati abuda kan pato si GPIIb/IIIa nitori aye ti aropo amino acid Konsafetifu kan ṣoṣo-lysine lati rọpo arginine. Nitorinaa, o yẹ ki o ni ipa itọju ailera to dara ni itọju ilowosi ti iṣọn-ẹjẹ iṣọn-alọ ọkan nla. Platelet glycoprotein IIb/IIIa awọn oogun antagonist olugba ti ni idagbasoke pupọ, ati lọwọlọwọ awọn iru awọn igbaradi mẹta wa ti o le ṣee lo ni ile-iwosan ni kariaye, abciximab, eptifibatide ati tirofiban. ). Iriri kekere ko wa ni lilo awọn antagonists olugba platelet glycoprotein GPIIb/IIIa ni Ilu China, ati pe awọn oogun to wa tun ni opin pupọ. Oogun kan ṣoṣo, tirofiban hydrochloride, wa lori ọja naa. Nitorinaa, platelet glycoprotein IIb tuntun ti ni idagbasoke. /IIIa antagonists olugba jẹ dandan. Eptifibatide ti ile jẹ ọja afarawe ti a ṣe nipasẹ Chengdu Sino Biological Products Co., Ltd.
Iyasọtọ
Iyasọtọ ti Awọn oogun Ikopọ Antiplatelet
Awọn oogun apapọ Antiplatelet le pin ni aijọju si awọn ẹka mẹta: 1. Cyclooxygenase-1 (COX-1) inhibitors, gẹgẹbi aspirin. 2. Idilọwọ awọn akojọpọ platelet ti a fa nipasẹ adenosine diphosphate (ADP), gẹgẹbi clopidogrel, prasugrel, cangrelor, ticagrelor, bbl awọn paati kẹmika tuntun ti a ṣopọ ati awọn ayokuro ti o munadoko lati oogun Kannada ibile.
