Terlipressin Acetate fun Esophageal Variceal Ẹjẹ
Apejuwe ọja
| Oruko | N- (N- (N-Glycylglycyl) glycyl) -8-L-lysinevasopressin |
| nọmba CAS | 14636-12-5 |
| Ilana molikula | C52H74N16O15S2 |
| Ìwúwo molikula | 1227.37 |
| Nọmba EINECS | 238-680-8 |
| Oju omi farabale | 1824.0± 65.0 °C (Asọtẹlẹ) |
| iwuwo | 1.46± 0.1 g/cm3 (Asọtẹlẹ) |
| Awọn ipo ipamọ | Tọju ni aaye dudu, oju-aye inert, Fipamọ sinu firisa, labẹ -15°C. |
| olùsọdipúpọ acidity | (pKa) 9.90± 0.15 (Asọtẹlẹ) |
Awọn itumọ ọrọ sisọ
[N-α-Triglycyl-8-lysine] -vasopressin; 130: PN: WO2010033207SEQID: 171claiMedprotein;1-Triglycyl-8-lysineVasopressin;Nα-Glycyl-glycyl-glycyl-[8-lysine] -vasopressin;Nα-Glycyl-glycyl-glycyl-lysine-vasopressin;Nα-Glycylglycylglycyl-vasopressin;Nα-Gly-Gly-Gly-8-Lys-vasopressin;Terlipressin, Terlipressine, Terlipressina, Terlipressin.
Apejuwe
Terlipressin, ti orukọ kemikali rẹ jẹ triglycyllysine vasopressin, jẹ igbaradi vasopressin sintetiki pipẹ-pipe.O jẹ iru prodrug kan, eyiti ko ṣiṣẹ funrararẹ.O ṣe nipasẹ aminopeptidase ni vivo lati “tusilẹ” laiyara lysine vasopressin ti nṣiṣe lọwọ lẹhin yiyọkuro awọn iṣẹku glycyl mẹta ni N-terminus rẹ.Nitorinaa, terlipressin n ṣiṣẹ bi ifiomipamo ti o tu lysine vasopressin silẹ ni iwọn imurasilẹ.
Ipa elegbogi ti terlipressin ni lati ṣe adehun iṣan iṣan iṣan ti iṣan ati dinku sisan ẹjẹ splanchnic (gẹgẹbi idinku sisan ẹjẹ ninu mesentery, Ọlọ, ile-ile, bbl), nitorinaa idinku sisan ẹjẹ ẹnu-ọna ati titẹ ọna abawọle.Ni apa keji, o tun le dinku pilasima Ipa ti ifọkansi renin, nitorinaa jijẹ sisan ẹjẹ kidirin, imudarasi iṣẹ kidirin ati jijẹ ito ninu awọn alaisan ti o ni iṣọn-ẹjẹ hepatorenal.Terlipressin lọwọlọwọ jẹ oogun nikan ti o le mu iwọn iwalaaye ti awọn alaisan ti o ni iṣọn-ẹjẹ variceal ti esophageal dara si.O jẹ lilo ni pataki ni itọju ile-iwosan ti iṣọn-ẹjẹ variceal.Ni afikun, terlipressin tun ti lo ni aṣeyọri ninu ẹdọ ati kidinrin.Ni gbogbogbo, o ṣee ṣe lati ṣe ipa ti o ni anfani ni isunmọ ifasilẹ mọnamọna ati isọdọtun ọkan ninu ọkan.Ti a ṣe afiwe pẹlu vasopressin, o ni ipa pipẹ, ko fa awọn ilolu ti o lewu, pẹlu fibrinolysis ati awọn ilolu to ṣe pataki ninu eto inu ọkan ati ẹjẹ, ati pe o rọrun lati lo (abẹrẹ inu iṣọn-ẹjẹ), eyiti o dara julọ fun itọju to lewu ati pataki.Igbala ati itọju awọn alaisan ti o ni itọsi.
