Leuprorelin Acetate ṣe ilana Itọjade ti Awọn homonu Gonadal
Apejuwe ọja
| Oruko | Leuprorelin |
| nọmba CAS | 53714-56-0 |
| Ilana molikula | C59H84N16O12 |
| Ìwúwo molikula | 1209.4 |
| Nọmba EINECS | 633-395-9 |
| Yiyi pato | D25 -31.7° (c = 1 ninu 1% acetic acid) |
| iwuwo | 1.44± 0.1 g/cm3 (Asọtẹlẹ) |
| Ipo ipamọ | -15°C |
| Fọọmu | Afinju |
| olùsọdipúpọ acidity | (pKa) 9.82± 0.15 (Asọtẹlẹ) |
| Omi solubility | Tiotuka ninu omi ni 1 miligiramu / milimita |
Awọn itumọ ọrọ sisọ
LH-RHLEUPROLIDE; LEUPROLIDE; LEUPROLIDE (ENIYAN); LEUPRORELIN;[DES-GLY10, D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-TẸLẸSINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHETIZ9); DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-ÌTÚSẸ̀FẸ́RẸ̀;
Pharmacological Ipa
Leuprolide, goserelin, triprelin, ati nafarelin jẹ ọpọlọpọ awọn oogun ti a lo nigbagbogbo ni iṣe ile-iwosan lati yọ awọn ovaries kuro fun itọju alakan igbaya premenopausal ati akàn pirositeti.(ti a tọka si bi GnRH-a oogun), GnRH-a oogun jẹ iru ni igbekalẹ si GnRH ati dije pẹlu awọn olugba GnRH pituitary.Iyẹn ni, gonadotropin ti a fi pamọ nipasẹ pituitary dinku, eyiti o yori si idinku nla ninu homonu ibalopo ti o farapamọ nipasẹ nipasẹ ọna.
Leuprolide jẹ homonu afọwọṣe ti gonadotropin (GnRH), peptide kan ti o ni awọn amino acids 9.Ọja yii le ṣe idiwọ iṣẹ ṣiṣe ti eto pituitary-gonadadal ni imunadoko, resistance si awọn ensaemusi proteolytic ati isunmọ si olugba GnRH pituitary ni okun sii ju GnRH, ati iṣẹ ṣiṣe ti igbega itusilẹ ti homonu luteinizing (LH) jẹ nipa awọn akoko 20. ti GnRH.O tun ni ipa inhibitory ti o lagbara lori iṣẹ pituitary-gonad ju GnRH.Ni ipele ibẹrẹ ti itọju, follicle stimulating hormone (FSH), LH, estrogen tabi androgen le jẹ alekun fun igba diẹ, ati lẹhinna, nitori idinku idahun ti ẹṣẹ pituitary, yomijade ti FSH, LH ati estrogen tabi androgen ti ni idinamọ, Abajade ni gbára lori ibalopo homonu.Awọn arun ibalopọ (gẹgẹbi akàn pirositeti, endometriosis, ati bẹbẹ lọ) ni ipa itọju ailera.
Ni bayi, iyọ acetate ti leuprolide jẹ akọkọ ti a lo ni ile-iwosan, nitori iṣẹ ti acetate leuprolide jẹ iduroṣinṣin diẹ sii ni iwọn otutu yara.Omi yẹ ki o sọnu.O le ṣee lo fun awọn oògùn castration itọju ti endometriosis ati uterine fibroids, aringbungbun precocious puberty, premenopausal igbaya akàn ati pirositeti akàn, ati ki o tun fun iṣẹ-ṣiṣe uterine eje ti o jẹ contraindicated tabi doko fun mora homonu ailera.O tun le ṣee lo bi premedication ṣaaju ki o to isọdọtun endometrial, eyiti o le din endometrium boṣeyẹ, dinku edema, ati dinku iṣoro ti iṣẹ abẹ.
