Awọn ọja
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Retatrutide
Retaglutide jẹ dipeptidyl peptidase-4 (DPP-4) tuntun inhibitor kilasi hypoglycemic oogun ti o le ṣe idiwọ ibajẹ ti glucagon-like peptide-1 (GLP-1) ati glucagon-igbẹkẹle insulin-itusilẹ polypeptide (GIP) nipasẹ DPP-4 henensiamu ninu ifun ati ẹjẹ, ti o fa awọn sẹẹli pancreatic ni ipa lori ifun ati ẹjẹ, nipa ṣiṣe gigun iṣẹ ṣiṣe insulini wọn. ipele basali ti hisulini ãwẹ, lakoko ti o dinku yomijade ti glucagon nipasẹ awọn sẹẹli α pancreatic, nitorinaa ni imunadoko diẹ sii ni iṣakoso suga ẹjẹ lẹhin ti prandial. O ṣe daradara ni awọn ofin ti ipa hypoglycemic, ifarada, ati ibamu.
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iṣuu soda Inclisiran
Inclisiran sodium API (Ero elegbogi Ti nṣiṣe lọwọ) ni a ṣe iwadi ni akọkọ ni aaye kikọlu RNA (RNAi) ati awọn itọju ailera inu ọkan. Gẹgẹbi siRNA ti o ni ilọpo meji ti o fojusi jiini PCSK9, o jẹ lilo ni iṣaaju ati iwadii ile-iwosan lati ṣe iṣiro awọn ọgbọn ipalọlọ jiini ti n ṣiṣẹ pipẹ fun idinku LDL-C (idaabobo lipoprotein iwuwo kekere). O tun ṣe iranṣẹ bi akojọpọ awoṣe fun ṣiṣewadii awọn ọna ṣiṣe ifijiṣẹ siRNA, iduroṣinṣin, ati awọn itọju ailera RNA ti a fojusi ẹdọ.
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Fmoc-Gly-Gly-OH
Fmoc-Gly-Gly-OH jẹ dipeptide ti a lo bi ipilẹ ile ipilẹ ni iṣelọpọ peptide ti o lagbara (SPPS). O ṣe ẹya awọn iṣẹku glycine meji ati N-terminus ti o ni aabo Fmoc, gbigba fun elongation pq peptide iṣakoso. Nitori iwọn kekere ti glycine ati irọrun, dipeptide yii ni a maa n ṣe iwadi ni gbogbo igba ti awọn iyipada ẹhin peptide, apẹrẹ ọna asopọ, ati awoṣe igbekalẹ ni awọn peptides ati awọn ọlọjẹ.
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Fmoc-Thr (tBu) -Phe-OH
Fmoc-Thr(tBu) -Phe-OH jẹ bulọọki ile dipeptide ti o wọpọ ti a lo ni iṣelọpọ peptide-alakoso ti o lagbara (SPPS). Ẹgbẹ Fmoc (9-fluorenylmethyloxycarbonyl) ṣe aabo fun N-terminus, lakoko ti ẹgbẹ tBu (tert-butyl) ṣe aabo pq ẹgbẹ hydroxyl ti threonine. Dipeptide ti o ni aabo yii ni a ṣe iwadi fun ipa rẹ ni irọrun elongation peptide daradara, idinku isọdi-ije, ati ṣe apẹẹrẹ awọn ero-tẹle kan pato ninu eto amuaradagba ati awọn ikẹkọ ibaraenisepo.
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AEEA-AEEA
AEEA-AEEA jẹ hydrophilic, spacer rọ ti o wọpọ ti a lo ninu peptide ati iwadii iṣọpọ oogun. O ni awọn iwọn orisun-ethylene glycol meji, ti o jẹ ki o wulo fun kikọ ẹkọ awọn ipa ti gigun asopọ ati irọrun lori awọn ibaraẹnisọrọ molikula, solubility, ati iṣẹ-ṣiṣe ti ibi. Awọn oniwadi nigbagbogbo lo awọn ẹya AEEA lati ṣe iṣiro bii awọn alafo ṣe ni ipa lori iṣẹ ti awọn conjugates antibody-oògùn (ADCs), awọn conjugates-oògùn peptide, ati awọn bioconjugates miiran.
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![Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide10-300x300.png)
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH
Apapọ yii jẹ aabo, itọsẹ lysine ti iṣẹ ṣiṣe ti a lo ninu iṣelọpọ peptide ati idagbasoke idapọ oogun. O ṣe ẹya ẹgbẹ Fmoc kan fun aabo N-terminal, ati iyipada pq ẹgbẹ pẹlu Eic (OtBu) (itọsẹ eicosanoic acid), γ-glutamic acid (γ-Glu), ati AEEA (aminoethoxyethoxyacetate). Awọn paati wọnyi jẹ apẹrẹ lati ṣe iwadi awọn ipa lipidation, kemistri spacer, ati itusilẹ oogun iṣakoso. O ti ṣe iwadii lọpọlọpọ ni aaye ti awọn ilana prodrug, awọn ọna asopọ ADC, ati awọn peptides ibaraenisepo awọ ara.
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![Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide9-300x300.png)
Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH
Apapọ yii jẹ itọsẹ lysine ti a ṣe atunṣe ti a lo ninu iṣelọpọ peptide, ni pataki fun ṣiṣe awọn ifọkansi tabi awọn conjugates peptide multifunctional. Ẹgbẹ Fmoc ngbanilaaye fun iṣelọpọ igbesẹ nipasẹ Fmoc solid-phase peptide synthesis (SPPS). Ẹwọn ẹgbẹ jẹ atunṣe pẹlu itọsẹ stearic acid (Ste), γ-glutamic acid (γ-Glu), ati awọn asopọ AEEA meji (aminoethoxyethoxyethoxyacetate), eyiti o pese hydrophobicity, awọn ohun-ini idiyele, ati aye to rọ. O jẹ iwadi ni igbagbogbo fun ipa rẹ ninu awọn eto ifijiṣẹ oogun, pẹlu awọn conjugates antibody-oògùn (ADCs) ati awọn peptides ti nwọle sẹẹli.
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Liraglutide Anti-Diabetics fun Iṣakoso suga ẹjẹ CAS NO.204656-20-2
Ohun elo ti nṣiṣẹ:Liraglutide (afọwọṣe ti glucagon-bi peptide-1 (GLP-1) ti a ṣe nipasẹ iwukara nipasẹ imọ-ẹrọ isọdọtun jiini).
Orukọ Kemikali:Arg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl))))-GLP-1[7-37]
Awọn eroja miiran:Disodium Hydrogen Phosphate Dihydrate, Propylene Glycol, Hydrochloric Acid ati/tabi Sodium Hydroxide (gẹgẹbi awọn oluyipada pH Nikan), Phenol, ati Omi fun Abẹrẹ.
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Leuprorelin Acetate ṣe ilana Itọjade ti Awọn homonu Gonadal
Orukọ: Leuprorelin
CAS nọmba: 53714-56-0
Ilana molikula: C59H84N16O12
Iwọn molikula: 1209.4
EINECS Nọmba: 633-395-9
Yiyi ni pato: D25 -31.7° (c = 1 ninu 1% acetic acid)
iwuwo: 1.44± 0.1 g/cm3(Asọtẹlẹ)
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Boc-His (Trt) -Aib-Gln (Trt)-Gly-OH
Boc-His (Trt) -Aib-Gln (Trt)-Gly-OHjẹ tetrapeptide ti o ni aabo ti a lo ninu iṣelọpọ peptide ati awọn ẹkọ igbekalẹ. Ẹgbẹ Boc (tert-butyloxycarbonyl) ṣe aabo fun N-terminus, lakoko ti awọn ẹgbẹ Trt (trtyl) ṣe aabo awọn ẹwọn ẹgbẹ ti histidine ati glutamine lati yago fun awọn aati aifẹ. Iwaju Aib (α-aminoisobutyric acid) ṣe igbelaruge awọn imudara helical ati mu iduroṣinṣin peptide ṣe. peptide yii ṣeyelori fun ṣiṣewadii kika peptide, iduroṣinṣin, ati bi scaffold fun sisọ awọn peptides ti nṣiṣe lọwọ biologically.
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BPC-157
BPC-157 API gba ilana iṣelọpọ alakoso to lagbara (SPPS):
Mimo giga: ≥99% (iwari HPLC)
Iyoku aimọ kekere, ko si endotoxin, ko si idoti irin ti o wuwo
Iduroṣinṣin ipele, atunṣe to lagbara, lilo ipele abẹrẹ atilẹyin
Ṣe atilẹyin giramu ati ipese ipele kilogram lati pade awọn iwulo ti awọn ipele oriṣiriṣi lati R&D si iṣelọpọ. -
CJC-1295
CJC-1295 API jẹ iṣelọpọ ni lilo imọ-ẹrọ peptide alakoso to lagbara (SPPS) ati ti sọ di mimọ nipa lilo HPLC lati ṣaṣeyọri mimọ giga ati aitasera ipele-si-ipele.
Awọn ẹya ara ẹrọ ọja:Mimọ ≥ 99%
Awọn olomi ti o ku kekere ati awọn irin eru
Ọfẹ Endotoxin, ipa ọna iṣelọpọ ti kii-immunogenic
Awọn iwọn asefara: mg si kg