Liraglutide Anti-Diabetics fun Iṣakoso suga ẹjẹ CAS NO.204656-20-2
Apejuwe ọja
| CAS | 204656-20-2 | Ilana molikula | C172H265N43O51 |
| Òṣuwọn Molikula | 3751.20 | Ifarahan | funfun |
| Ibi ipamọ Ipo | Ina resistance, 2-8 ìyí | Package | Aluminiomu bankanje apo / vial |
| Mimo | ≥98% | Gbigbe | Tutu Pq ati itura ipamọ ifijiṣẹ |
Awọn eroja ti Liraglutide
Ohun elo ti nṣiṣẹ:
Liraglutide (afọwọṣe ti glucagon-bi peptide-1 (GLP-1) ti a ṣe nipasẹ iwukara nipasẹ imọ-ẹrọ isọdọtun jiini).
Orukọ Kemikali:
Arg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl))))-GLP-1[7-37]
Awọn eroja miiran:
Disodium Hydrogen Phosphate Dihydrate, Propylene Glycol, Hydrochloric Acid ati/tabi Sodium Hydroxide (gẹgẹbi awọn oluyipada pH Nikan), Phenol, ati Omi fun Abẹrẹ.
Ohun elo
Àtọgbẹ Iru 2
Liraglutide ṣe ilọsiwaju iṣakoso ti glukosi ẹjẹ.O dinku hyperglycemia ti o ni ibatan ounjẹ (fun awọn wakati 24 lẹhin iṣakoso) nipa jijẹ yomijade hisulini (nikan) nigbati o ba nilo nipasẹ jijẹ awọn ipele glukosi, idaduro isọdi inu, ati didimu yomijade glucagon prandial.
O dara fun awọn alaisan ti suga ẹjẹ wọn ko ni iṣakoso lẹhin iwọn lilo ti o pọju ti metformin tabi sulfonylureas nikan.O ti lo ni apapo pẹlu metformin tabi sulfonylureas.
O ṣe ni ọna ti o gbẹkẹle glukosi, afipamo pe yoo mu yomijade hisulini ṣiṣẹ nikan nigbati awọn ipele glukosi ẹjẹ ba ga ju deede lọ, ni idilọwọ “overshoot”.Nitoribẹẹ, o ṣe afihan eewu aibikita ti hypoglycemia.
O ni agbara fun didi apoptosis ati isọdọtun ti awọn sẹẹli beta (ti a rii ninu awọn ẹkọ ẹranko).
O dinku ifẹkufẹ ati idilọwọ ere iwuwo ara, bi o ṣe han ninu ikẹkọ ori-si-ori dipo glimepiride.
Pharmacological Action
Liraglutide jẹ afọwọṣe GLP-1 pẹlu 97% homology lẹsẹsẹ si GLP-1 eniyan, eyiti o le sopọ mọ ati mu olugba GLP-1 ṣiṣẹ.Olugba GLP-1 jẹ ibi-afẹde ti GLP-1 abinibi, homonu incretin endogenous ti o ṣe agbega yomijade hisulini ti o gbẹkẹle ifọkansi glukosi lati awọn sẹẹli beta pancreatic.Ko dabi GLP-1 abinibi, elegbogi ati awọn profaili elegbogi ti liraglutide ninu eniyan dara fun ilana iwọn lilo lojumọ.Lẹhin abẹrẹ subcutaneous, ilana rẹ ti igbese gigun pẹlu: idapọ ti ara ẹni ti o fa fifalẹ gbigba;asopọ pẹlu albumin;Iduroṣinṣin henensiamu ti o ga ati nitorinaa gigun pilasima idaji-aye.
Iṣẹ ṣiṣe ti liraglutide jẹ ilaja nipasẹ ibaraenisepo pato rẹ pẹlu olugba GLP-1, ti o yorisi ilosoke ninu adenosine monophosphate cyclic (cAMP).Liraglutide ṣe iwuri yomijade hisulini ni ọna ti o gbẹkẹle ifọkansi glukosi, lakoko ti o dinku yomijade glucagon pupọ ni ọna ti o gbẹkẹle ifọkansi glukosi.
Nitorinaa, nigbati glukosi ẹjẹ ba dide, yomijade hisulini yoo mu, lakoko ti yomijade glucagon ti ni idiwọ.Ni idakeji, liraglutide dinku yomijade hisulini lakoko hypoglycemia laisi ni ipa lori yomijade glucagon.Ẹrọ hypoglycemic ti liraglutide tun pẹlu gigun diẹ ti akoko ṣofo inu.Liraglutide dinku iwuwo ara ati ibi-ọra ti ara nipasẹ idinku ebi ati gbigbemi agbara.
