Linaclotide fun Awọn Ẹjẹ inu Ifun 851199-59-2
Apejuwe ọja
| Oruko | Linaclotide |
| nọmba CAS | 851199-59-2 |
| Ilana molikula | C59H79N15O21S6 |
| Ìwúwo molikula | 1526.74 |
Awọn itumọ ọrọ sisọ
Linaclotide, Linaclotide, Linaelotide Acetate, Linaelotide; CY-14; Liclotide; Argpessin, L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl- L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)
Apejuwe
Linaclotide, ẹya peptide sintetiki ti o ni awọn amino acids 14, ni ibatan si idile guanosine peptide endogenous ati pe o jẹ GC-C (guanylate) Cyclase-C ti FDA ti a fọwọsi nikan ni awọn oogun agonist fun itọju iṣọn ifun irritable pẹlu àìrígbẹyà (IBS- C) ati àìrígbẹyà idiopathic onibaje (CIC) ninu awọn agbalagba.
Kemikali Properties
Linaclotide jẹ funfun si pa-funfun amorphous lulú;die-die tiotuka ninu omi ati olomi soda kiloraidi ojutu (0.9%).
Bi o ti n ṣiṣẹ
Linaclotide jẹ agonist olugba olugba guanylate cyclase-C (GCCA) pẹlu analgesic visceral mejeeji ati iṣẹ endocrine.Mejeeji linaclotide ati metabolite ti nṣiṣe lọwọ le sopọ mọ olugba guanylate cyclase-C (GC-C) lori oju luminal ti epithelium oporoku kekere.Ninu awọn awoṣe ẹranko, linaclotide dinku irora visceral ati ki o pọ si ọna gbigbe nipa ikun nipasẹ imuṣiṣẹ ti GC-C, ati ninu eniyan, oogun naa tun mu irekọja si colonic.Abajade ti imuṣiṣẹ GC-C pọ si intracellular ati extracellular cGMP (cyclic guanosine monophosphate) awọn ifọkansi.Extracellular cGMP le dinku iṣẹ ṣiṣe ti awọn okun nafu ara irora ati dinku irora visceral ni awọn ẹranko awoṣe.Intracellular cGMP le mu awọn yomijade ti kiloraidi ati bicarbonate ninu awọn kekere ifun nipa a Muu ṣiṣẹ CFTR (cystic fibrosis transmembrane conductance olutọsọna), eyi ti bajẹ-fa awọn ilosoke ti kekere ifun omi yomijade ati awọn iyara ti kekere oporoku irekọja.
FAQ
Ṣe o ṣe iṣeduro ailewu ati aabo ifijiṣẹ awọn ọja?
Bẹẹni, a nigbagbogbo lo awọn apoti okeere ti o ga julọ.A tun lo iṣakojọpọ eewu pataki fun awọn ẹru ti o lewu ati awọn ẹru ibi ipamọ otutu ti a fọwọsi fun awọn nkan ifarabalẹ iwọn otutu.Iṣakojọpọ pataki ati awọn ibeere iṣakojọpọ ti kii ṣe boṣewa le fa idiyele afikun.
Bawo ni nipa awọn idiyele gbigbe?
Iye owo gbigbe da lori ọna ti o yan lati gba awọn ẹru naa.KIAKIA jẹ deede iyara julọ ṣugbọn tun gbowolori ọna.Nipa ẹru okun jẹ ojutu ti o dara julọ fun awọn oye nla.Awọn oṣuwọn ẹru gangan a le fun ọ nikan ti a ba mọ awọn alaye ti iye, iwuwo ati ọna.Jọwọ kan si wa fun alaye siwaju sii.
